Topoisomerase Overview

Topoisomerases are isomerase enzymes that acts on the topology of DNA. They were first discovered by Harvard Professor James C. Wang. The double-helical configuration that DNA strands naturally reside in makes them difficult to separate, and yet they must be separated by helicase proteins if other enzymes are to transcribe the sequences that encode proteins, or if chromosomes are to be replicated. In so-called circular DNA, in which double helical...