Definition
Hyperthyroidism is a condition caused by an overactive thyroid gland. The gland makes too much T4 and T3 hormones. Hormones are substances that affect and control many important functions in the body.
Symptoms
Additional symptoms that may be associated with this disease:
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Definition
Hyperthyroidism is a condition caused by an overactive thyroid gland. The gland makes too much T4 and T3 hormones. Hormones are substances that affect and control many important functions in the body.
Symptoms
Additional symptoms that may be associated with this disease:
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Causes
The thyroid gland is located in the neck. It produces several hormones which control the way that every cell in the body uses energy ( metabolism ). The thyroid is part of the endocrine system.
Hyperthyroidism or thyrotoxicosis occurs when the thyroid releases too many of its hormones over a short (acute) or long (chronic) period of time. Many diseases and conditions can cause this problem, including:
- Graves disease
- Non-cancerous growths of the thyroid gland or pituitary gland
- Tumors of the testes or ovaries
- Inflammation (irritation and swelling) of the thyroid due to viral infections or other causes
- Ingestion (taking in through the mouth, such as in eating) of large amounts of thyroid hormone
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Treatment
Treatment varies depending on the cause of the condition and the severity of symptoms. Hyperthyroidism is usually treated with antithyroid medications, radioactive iodine (which destroys the thyroid and stops the excess production of hormones), or surgery to remove the thyroid.
If the thyroid must be removed with radiation or surgery, replacement thyroid hormones must be taken for the rest of the person's life.
Beta-blockers like propranolol are used to treat some of the symptoms including rapid heart rate, sweating, and anxiety until the hyperthyroidism can be controlled.
Possible Complications
- Heart-related complications include rapid heart rate , congestive heart failure , and atrial fibrillation .
- Thyroid crisis or storm is an acute worsening of the symptoms of hyperthyroidism that may occur with infection or stress. Fever , decreased mental alertness, and abdominal pain may occur, and immediate hospitalization is needed.
- Hyperthyroidism increases the risk for osteoporosis .
- There may be complications related to surgery, including visible scarring of the neck, hoarseness due to nerve damage to the voice box, and a low calcium level because of damage to the parathyroid glands.
- Complications may be related to replacement of thyroid hormones. If too little hormone is given, symptoms of under-active thyroid can occur including fatigue, increased cholesterol levels, mild weight gain, depression, and slowing of mental and physical activity. If too much hormone is given, the symptoms of hyperthyroidism will come back.
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Outlook (Prognosis)
Hyperthyroidism caused by Graves disease is usually progressive and has many associated complications, some of which are severe and affect quality of life.
These include complications caused by treatment such as use of radioactive iodine, surgery, and medications to replace thyroid hormones. However, hyperthyroidism is generally treatable and rarely fatal.
Prevention
There are no general prevention measures to prevent hyperthyroidism.
Exams and Tests
Physical examination may reveal thyroid enlargement or goiter. Vital signs (temperature, pulse, rate of breathing, blood pressure) show increased heart rate . Systolic blood pressure (the first number in a blood pressure reading) may be high.
Laboratory tests that evaluate thyroid function:
- Serum TSH is usually low
- T3 and free T4 are usually high
This disease may also alter the results of the following tests:
References
AACE Thyroid Task Force. American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for the Evaluation and Treatment Of Hyperthyroidism and Hypothyroidism. Endocr Pract . 2002;8 (6).
