Secretin is a peptide hormone produced in the S cells of the duodenum in the crypts of Lieberkühn. Its primary effect is to regulate the pH of the duodenal contents via the control of gastric acid secretion and buffering with bicarbonate. It was the first hormone to be discovered . Secretin is secreted in response to low duodenal pH due to chyme, which contains hydrochloric acid, entering from the stomach....
gastrin is a hormone that stimulates secretion of gastric acid by the parietal cells of the stomach. It is produced and released by G cells in the stomach and duodenum....
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