Proton pump inhibitors are a group of drugs whose main action is pronounced and long-lasting reduction of gastric acid production. They are the most potent inhibitors of acid secretion available today. The group followed and has largely superseded another group of pharmaceuticals with similar effects, but different mode-of-action, called H2-receptor antagonists. These drugs are among the most widely-selling drugs in the world as a result of their outstanding efficacy and...
H1 inhibitors aren't intended to "completely suppress" acid production, rather to keep in within physiologic constraints. Certainly, all absence of acid in the stomach isn't good, so PPIs aren't...