Penlac Overview

Ciclopirox olamine is a synthetic antifungal agent for topical dermatologic use. Antifungal activity is produced by its chelation with critical trivalent cations resulting in downstream effects. Loss of function of certain catalase and peroxidase enzymes have been implicated the mechanism of action as well as various other components of cellular metabolism. In a study conducted to further elucidate ciclopiroxs' mechanism, several Saccharomyces cerevisiae mutants were screened and tested. Results from...

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