A paraprotein is an abnormal protein in the urine or blood, most often associated with benign MGUS , where they remain "silent", and multiple myeloma. An excess in the blood is known as paraproteinemia. These are immunoglobulins or immunoglobulin light-chains that are produced by the clonal proliferation of plasma cells. Paraproteins form a narrow band, or 'spike' in protein electrophoresis as they are all exactly the same protein. Monoclonal free...
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