Ototoxicity is damage of the ear , specifically the cochlea or auditory nerve and sometimes the vestibulum, by a toxin . A number of drugs have been associated with damage to the cochlea. The best known are aminoglycoside antibiotics, aspirin, nicotine, some chemotherapy agents and some loop diuretics such as furosemide. Erythromycin and some other macrolide antibiotics can induce temporary deafness, which resolves upon withdrawal of the drug. Other chemicals...
Ototoxicity is defined as the tendency of certain therapeutic agents to cause functional impairment and cellular degeneration of the inner ear and of the eighth cranial nerve. Ototoxicity may be...