Maprotiline Overview

Maprotiline Guide

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  • Summary
  • Why it is Prescribed
  • Important Warning
  • How it Works
  • Other Information
  • Other Uses
  • Overdose
  • Precautions
  • Possible Side Effects
  • Special Dietary Concerns
  • Storage Conditions

Why it is Prescribed

Maprotiline is used to treat depression, bipolar disorder (manic depressive disorder; a disease that causes episodes of depression, episodes of mania, and other abnormal moods), and anxiety. Maprotiline is in a class of medications called tetracyclic antidepressants. It works by increasing the amounts of certain natural substances in the brain that are needed to maintain mental balance.


Important Warning

A small number of children, teenagers, and young adults (up to 24 years of age) who took antidepressants ('mood elevators') such as maprotiline during clinical studies became suicidal (thinking about harming or killing oneself or planning or trying to do so). Children, teenagers, and young adults who take antidepressants to treat depression or other mental illnesses may be more likely to become suicidal than children, teenagers, and ...


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Encyclopedia: Maprotiline

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Maprotiline is a tetracyclic antidepressant. It is a strong norepinephrine reuptake inhibitor with only weak effects on serotonin and dopamine reuptake. It exerts blocking effects at the following postsynaptic receptors: , Strong : alpha1 , Moderate : 5-HT2, muscarinic, H1, D2 , Weak : alpha2 , Extremely weak : 5-HT1 The pharmacologic profile of Maprotiline explains its antidepressant, sedative, anxiolytic, sympathomimetic, and anticholinergic activities. Additionally, it shows a strong antagonism...


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Forum Search

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  • Women with ADD are you cranky? - 2 replies

    (maprotiline, bupropion) appear to be ineffective. Interestingly, the onset of action Here is some info on how SSRI's help smooth out our lives. Serotonin reuptake inhibitors for...

    Oct 11, 2004

  • FDA Warning About Antidepressant Medications - 4 replies

    (maprotiline) Marplan (isocarboxazid) Nardil (phenelzine sulfate) nefazodone HCl Norpramin FDA Proposes New Warnings About Suicidal Thinking, Behavior in Young Adults Who Take Antidepressant...

    May 02, 2007

  • Summertime and Our Meds - 2 replies

    Maprotiline (Ludiomil) o Phenylizine (Nardil) o Protriptyline (Vivactil) o Trazodone (Desyrel) o Part 1: Heatstroke Yay!!! Summer is here! Summer means sunny days, warm weather, grilling out...

    Apr 02, 2008

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Question and Answer

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What are side effects of not eating while on antidepressants?
I take maprotiline (http://www.healthline.com/multumcontent/maprotiline#H2). I've been trying to lose some weight lately so i haven't...

Not eating is not a way to lose weight, it is an eating disorder. What you need to do is eat healthy food 3-5 times per day. Get plenty of...

Asked by omfgska - 13 months ago

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    Maprotiline hydrochloride, USP is a tetracyclic antidepressant, available as 25 mg, 50 mg and 75 mg tablets for oral administration. Its chemical name...


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    Maprotiline hydrochloride, USP is a tetracyclic antidepressant, available as 25 mg, 50 mg and 75 mg tablets for oral administration. Its chemical name...


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    Maprotiline hydrochloride, USP is a tetracyclic antidepressant, available as 25 mg, 50 mg and 75 mg tablets for oral administration. Its chemical name...


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Are you taking multiple medications? Double Check MD can check for interactions and side effects resulting from your drug regimen. You can also enter symptoms and results of laboratory tests to determine if any of your medications are the cause.

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