- Summary
- Definition
Reviewed By Benjamin W. Van Voorhees, M.D.
Definition
Intrinsic factor is a protein produced by glands in the stomach lining. It is needed for the intestines to absorb vitamin B12 . A lack (deficiency) of enough intrinsic factor can cause pernicious anemia . Such deficiencies can be caused by surgical removal of the stomach, inherited conditions, or other diseases.
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Encyclopedia: Intrinsic Factor
Intrinsic factor is a glycoprotein produced by the parietal cells of the stomach. It is necessary for the absorption of vitamin B later on in the terminal ileum. Upon entry into the stomach, vitamin B becomes bound to one of two B binding proteins present in gastric juice. In the less acidic environment of the small intestine, these proteins dissociate from the vitamin, enabling it to bind to intrinsic factor...
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