Definition
Hypogonadism is when the sex glands produce little or no hormones. In men, these glands (gonads) are the testes; in women, they are the ovaries.
Symptoms
In girls, hypogonadism during childhood will result in lack of menstruation and breast development and short height. If hypogonadism occurs after puberty, symptoms include loss of menstruation, low libido, hot flashes, and loss of body hair.
In boys, hypogonadism in childhood results in lack of muscle and beard development and growth problems. In men the usual complaints are sexual dysfunction, decreased beard and body hair, breast enlargement, and muscle loss.
If a brain tumor is present (central hypogonadism) there may be headaches or visual loss, or symptoms of other hormonal deficiencies (such as hypothyroidism ). In the case of the most common ...
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Definition
Hypogonadism is when the sex glands produce little or no hormones. In men, these glands (gonads) are the testes; in women, they are the ovaries.
Symptoms
In girls, hypogonadism during childhood will result in lack of menstruation and breast development and short height. If hypogonadism occurs after puberty, symptoms include loss of menstruation, low libido, hot flashes, and loss of body hair.
In boys, hypogonadism in childhood results in lack of muscle and beard development and growth problems. In men the usual complaints are sexual dysfunction, decreased beard and body hair, breast enlargement, and muscle loss.
If a brain tumor is present (central hypogonadism) there may be headaches or visual loss, or symptoms of other hormonal deficiencies (such as hypothyroidism ). In the case of the most common pituitary tumor, prolactinoma, there may be a milky breast discharge. People with anorexia nervosa (excessive dieting to the point of starvation) also may have central hypogonadism.
Causes
The cause of hypogonadism may be "primary" or "central." In primary hypogonadism, the ovaries or testes themselves do not function properly. Some causes of primary hypogonadism include:
The most common genetic disorders that cause primary hypogonadism are Turner syndrome (in women) and Klinefelter syndrome (in men).
In central hypogonadism, the centers in the brain that control the gonads (hypothalamus and pituitary) do not function properly. Some causes of central hypogonadism include
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Treatment
Hormone-based medicines are available for men and women. Estrogen comes in the form of a patch or pill. Testosterone can be given by using a patch, a product soaked in by the gums, a gel, or by injection.
For women who have not had their uterus removed, combination treatment with estrogen and progesterone is often recommended to decrease the chances of developing endometrial cancer. In addition, low dose testosterone can be added for women with hypogonadism who have a low sex drive.
In some women, injections or pills can be used to stimulated ovulation. Injections of pituitary hormone may be used to help male patients produce sperm. In others, surgery and radiation therapy may be needed.
Possible Complications
In women, hypogonadism may cause infertility . Menopause is a form of naturally occurring hypogonadism, which can cause hot flashes, vaginal dryness, and irritability as a woman's estrogen levels fall. The risk of osteoporosis and heart disease increase after menopause.
Some women with hypogonadism opt to take estrogen therapy , particularly those who have early menopause (premature ovarian failure). However, there is a small but significant increase in risk for breast cancer and heart disease with use of hormone replacement for treatment of menopause.
In men, hypogonadism results in loss of sex drive and may cause weakness, impotence, infertility, and osteoporosis. Men normally experience some decline in testosterone as they age, but it is not as dramatic or steep as the decline in sex hormones experienced by women.
Outlook (Prognosis)
Many forms of hypogonadism are potentially treatable and have a good prognosis.
Prevention
Maintain normal body weight and healthy eating habits to prevent anorexia nervosa. Other causes may not be preventable.
Exams and Tests
Tests may be done that check estrogen level (women) and testosterone level (men) as well as FSH level and LH level , the pituitary hormones that stimulate the gonads. Other tests may include a thyroid level; sperm count ; prolactin level (milk hormone); blood tests for anemia, chemistries, and iron; and genetic analysis.
Sometimes imaging is necessary, such as a sonogram of the ovaries. If pituitary disease is suspected, an MRI or CT scan of the brain may be done.
