In medicine , a granuloma is a nodule consisting mainly of epithelioid macrophages and other inflamatory and immune cells as well as extracellular matrix. They are often surrounded by a lymphocyte cuff or fibrosis. Granulomas form when the immune system attempts to fend off and isolate an antigen. The antigen can be an infectious pathogen or a foreign body but in many cases granulomas form without apparent cause in autoimmune...
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