Dopamine Hypothesis Of Schizophrenia Overview

The dopamine hypothesis of schizophrenia or the dopamine hypothesis of psychosis is a model attributing symptoms of schizophrenia to a disturbed and hyperactive dopaminergic signal transduction. The model draws evidence from the observation that a large number of antipsychotics have DA-antagonistic effects. The theory, however, does not posit dopamine overabundance as a complete explanation for schizophrenia. Some researchers have suggested that dopamine systems in the mesolimbic pathway may contribute to...