Corticotropin Releasing Hormone Overview

Corticotropin-releasing hormone , originally named corticotropin-releasing factor , and also called corticoliberin, is a polypeptide hormone and neurotransmitter involved in the stress response. Corticotropin-releasing hormone is a 41-amino acid peptide derived from a 191-amino acid preprohormone. CRH is secreted by the paraventricular nucleus of the hypothalamus in response to stress. Marked reduction in CRH has been observed in association with Alzheimer disease, and autosomal recessive hypothalamic corticotropin deficiency has multiple...