Understanding Non-Hodgkins Lymphoma from The National Cancer Institute
Non-Hodgkins Lymphoma is any of a large group of cancers of the immune system. Non-Hodgkin lymphomas can occur at any age and are often marked by enlarged lymph nodes, fever, and weight loss. There are many different types of non-Hodgkin lymphoma, which can be divided into aggressive (fast-growing) and indolent (slow-growing) types and can be classified as either B-cell or T-cell non-Hodgkin lymphoma. B-cell non-Hodgkin lymphomas include Burkitt lymphoma, diffuse large B-cell lymphoma, follicular lymphoma, immunoblastic large cell lymphoma, precursor B-lymphoblastic lymphoma, and mantle cell lymphoma. T-cell non-Hodgkin lymphomas include mycosis fungoides, anaplastic large cell lymphoma, and precursor T-lymphoblastic lymphoma. Lymphomas related to lymphoproliferative disorders following bone marrow or stem cell transplantation are usually B-cell non-Hodgkin lymphomas. Prognosis and treatment depend on the stage and type of disease. Also called NHL.
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Beta-thalassemia is one of a group of inherited blood disorders known as thalassemias. Beta-thal is recessive; a person must inherit two copies of a mutated beta globin gene (one from each parent) to develop symptoms. The beta globin mutation may have developed to act in conjunction with sickle cell as protective measures against malaria.
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Sickle cell disease is common in many regions of the world where mosquito-borne malaria is present. It is believed that people who carry only one sickle cell mutation (they do not have the disease) can tolerate malaria better than people who carry no mutations. This may be why the mutation persists in the population despite the high mortality associated with untreated sickle cell disease.
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